D 110bp 120bp penetrant, autosomal 11-12. The figure below shows the pedigree of
ID: 132609 • Letter: D
Question
D 110bp 120bp penetrant, autosomal 11-12. The figure below shows the pedigree of a family in which a completely dominant disease is transmitted through three generations. The alleles for a SNP locus are shown (A or C). The disease allele is rare and has a single origin in the pedigree. AA Mating AC d. ting Mating D A AC AA AC AA AC CC AC CC 11. Which of the three matings is non-informative (cannot provide Information about linkage) that we know the phase of the affected female in Mating 1? A. Mating1 8 Mating 2 C. Mating 3 D. None of the above 12. Assuming linkage between the disease gene and the SNP locus, what is the genetic distance between the two loci? A 7 m.u. 9. 10 m.u C. 14 m.u. D. 20 m.u 3. When male insects that are homozygous for several translocations are mated with normal females A. The fertility of these male insects would be reduced B. The F1 insects would be heterozygous for several translocations. C. The fertility of the F1 insects would be reduced. Both B and C A, B, and CExplanation / Answer
11) Mating 2 will be less informative. This is because in mating 2, the male is homozygous for AA. The genotype of the affected offsprings are also AA. So, we cannot draw any conclusions regarding genetic linkage from mutation 2. So, the answer for this question is option B.
12) The distance between two loci in a genetic linkage is 10 m.u.
13) When males that are homozygous for translocation are mated with normal females, all their F1 insects would be heterozygotes and their fertility would be less since there is only one normal gene. So, the answer for this question is option D.
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