can someone help and explain the type of mutations for DNa mutation 1-3 and the

Question

can someone help and explain the type of mutations for DNa mutation 1-3 and the what happen whether it is insertion or deletion etc

Gene Expression Worksheet Templae ONA Amine Acsd Sequence TAT | TAA | cca | CAA | TAA | ATT | ACT | ACT | CCC Template DNA Amine Acid Sequence Template DNA TAT TAC | CCA | CIA | TAA | TIA | CTA | CTC CCC Amino Acid Sequence Template DNA TAT TAC CCA CAA TAA ATTACT CCC ACT Amino Acid Sequence Second letter Phe UCU UCA uau UAA Stop UGA Stop UAG Stop UGG Trp CAU Guu cuc cco ACU AUC e AGC UG Met ACG Gcu AUU AAU GUU GAU GAC IAsp UAaco God Gud

Explanation / Answer

Ans. #1. Original Sequence:

Complementary DNA: ATAATGGGTGTTATTTAATGATGAGGG

           Template DNA: TATTACCCACAATAAATTACTACTCCC

                           mRNA: AUAAUGGGUGUUAUUUAAUGAUGAGGG

                AA Sequence: Ile-Met-Gly-Val-Ile-*STOP*

# Mutation 1:

Complementary DNA: ATAATTGGTGTTATTTAATGATGAGGG

           Template DNA: TATTAACCACAATAAATTACTACTCCC

                           mRNA: AUAAUUGGUGUUAUUUAAUGAUGAGGG

                AA Sequence: Ile-Ile-Gly-Val-Ile-*STOP*

            Type of mutation: Missense mutation

# The point mutation that changes amino acid sequence is called a Missense Mutation (compared to original sequence).

# Mutation 2:

Complementary DNA: ATAATGGGTGTTATTAATGATGAGGGG

           Template DNA: TATTACCCACAATAATTACTACTCCCC

                           mRNA: AUAAUGGGUGUUAUUAAUGAUGAGGGG

                AA Sequence: Ile-Met-Gly-Val-Ile-Asn-Asp-Glu-Gly

            Type of mutation: Nonstop mutation

# A mutation that converts a STOP codon into an amino acid codon is called a nonstop mutation.

# Mutation 3:

Complementary DNA: ATAATGGGTGTTATTTAATGAGGGTGA

           Template DNA: TATTACCCACAATAAATTACTCCCACT

                           mRNA: AUAAUGGGUGUUAUUUAAUGAGGGUGA

                AA Sequence: Ile-Met-Gly-Val-Ile-*STOP*

            Type of mutation: Silent mutation

# The point mutation that does not change amino acid sequence is called a Silent Mutation. Silent point mutation arise due to substitution of one base with another base AND the mutated codon codes the same amino acid as wild type. It does not affect the amino acid sequence of resultant proteins.

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