1. What molecular rearrangement typically causes Burkitt\'s Lymphoma? Why is not
ID: 134302 • Letter: 1
Question
1. What molecular rearrangement typically causes Burkitt's Lymphoma?
Why is not surprising that the tumor that is being created by this molecular rearrangement is a type of lymphoma (as opposed to other types of cancer)?
2. What is the normal role for growth factors and their receptors in the body? What structural features are seen in most receptors?
3. Describe some of the types of internal "ligand-receptor" modular interactions can be seen with cytoplasmic and nuclear proteins.
4. Describe where integrin proteins are located and what other types of molecules they are connected to on each of their ends. In what ways are integrins involved in more than just structural connections?
Explanation / Answer
1. Burkitt's Lymphoma is caused by dysregulation of c-myc gene caused as the result of chromosome translocation. c-myc gene regulates B-cell (a lymphocyte) production. So dysregulation causes abnormal production of B-cell which results in lymphoma.
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