Can you someone please explain the concept behind this. I\'m more interested in
ID: 136452 • Letter: C
Question
Can you someone please explain the concept behind this. I'm more interested in learning how to approach the problem than the answer. How does the body weight of a person effect Vd values? And also, in the table where the Vd values are presented for each drug for example Drug A has a Vd = 16.0 + 4. What does the 4 mean? How do you interepret these values. I know it's a lot of questions but I'm really stuck.
Calculate the volume of distribution for a 70-kilogram man for one of the four drugs listed in the table below. Using your calculations, interpret the implications that can be inferred from the value you calculated. In your post, include your calculations and interpretation. Volume of Distribution Drug Drug A Drug B Drug C Drug D Volume of Distribution (L/kg) 16.0+4 1.1 0.2 0.07+0.02 0.23+0.09 After making your initial post, read the posts of other students and respond to one other student who had a different interpretation than you. Explain why your interpretations are different. If you think one of you is incorrect, explain why and if it's you, change your response. You will not be able to read anyone's post until you've posted your own.Explanation / Answer
The volume of distribution is the amount of drug in the body that means dose to the concentration of the drug distributed in the body that measured in blood, plasma, or tissue water. The concentration of the drug is the distribution of the drug in the extracellular fluid into tissues. The peak level is measured by taking the blood sample. The value 16, 1.1, 0.07, 0.23 indicates the amount of drug in the body and 4, 0.2, 0.02, 0.09 indicates peak level of drug in the blood. The apparent volume is the exact volume of the extent of the drug in the body.
Volume of distribution = Total amount of drug in the body / Drug blood plasma concentration.
Step 1:
Drug A = 16.0 +4
By applying formula,
Vd = 16 / 4 = 4.
The patient weighs 70kg.
Therefore 0.057L/Kg.
The apparent volume of distribution for Drug A is 0.057L/kg.
Step 2:
Drug B = 1.1 + 0.2
Vd = 1.1 / 0.2
= 5.5
By considering the patient's weight = 5.5 / 70 = 0.078
The appaarent volume of drug distribution for Drug B is 0.078L/kg.
Step 3:
Drug C = 0.07 + 0.02
Vd = 0.07/0.02
= 3.5
By dividing the patient weight = 3.5 / 70 = 0.05L/kg.
The apparent volume of distribution for Drug C is 0.05L/kg.
Step 4:
Drug D = 0.23 + 0.09
Vd = 0.23/0.09
= 2.5
By dividing the patient weight, = 2.5/ 70 = 0.03
The apparent volume of distribution for Drug D is 0.03L/Kg.
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