Kornberg utilized 4 puzzle pieces to provethat DNA is antiparallel: 1) Chargaff\
ID: 1370 • Letter: K
Question
Kornberg utilized 4 puzzle pieces to provethat DNA is antiparallel: 1) Chargaff's base complementation, 2)DNA is synthesized in the 5' to 3' direction, 3) snake venomphosphodiesterase cuts the phosphate from the 5' carbon leaving itattached to the 3' carbon of the nearest upstream neighbor, 4) aradioactively labeled nucleotide triphosphate like ATP would giveus the frequency that "A" is next to each of the 4 possibleupstream nucleotide bases. With these 4 puzzle pieces, explain howwe know that DNA is antiparallel.Write these 4 puzzle pieces on a blank paper. Draw two patternswith a GC pair above an AT pair, one pattern being parallel and thesecond being antiparallel. If you know the frequency of a labeled Ahanding it off to G as its nearest upstream neighbor, what isneeded now to prove that DNA is antiparallel? I don't even know where to start. I will rate you rightaway. Please help me!
Kornberg utilized 4 puzzle pieces to provethat DNA is antiparallel: 1) Chargaff's base complementation, 2)DNA is synthesized in the 5' to 3' direction, 3) snake venomphosphodiesterase cuts the phosphate from the 5' carbon leaving itattached to the 3' carbon of the nearest upstream neighbor, 4) aradioactively labeled nucleotide triphosphate like ATP would giveus the frequency that "A" is next to each of the 4 possibleupstream nucleotide bases. With these 4 puzzle pieces, explain howwe know that DNA is antiparallel.
Write these 4 puzzle pieces on a blank paper. Draw two patternswith a GC pair above an AT pair, one pattern being parallel and thesecond being antiparallel. If you know the frequency of a labeled Ahanding it off to G as its nearest upstream neighbor, what isneeded now to prove that DNA is antiparallel? I don't even know where to start. I will rate you rightaway. Please help me!
Explanation / Answer
Hydrogen bonds form between purines & pyrimidines Planar& hydrophobically stacked Stabilizes the double helix Createsanti-parallel strands A - T = 2 H-bonds G - C = 3 H-bonds Hydrogen bonds form between purines & pyrimidines Planar& hydrophobically stacked Stabilizes the double helix Createsanti-parallel strands A - T = 2 H-bonds G - C = 3 H-bondsDNA polyermase adds nucleotides to complimentary strand of DNA inthe 5' to 3' direction ONLY! Lagging strand needs RNA primers tobegin (10 N.T)b/c DNA is antiparallel, replication must work inopposite directionsLeading Strand this website might help you http://www.rcscsd.org/apbio/notes_DNA.htm
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