A protein in the Er is normally converted from EndoDResistant to EndoDSensitive
ID: 13720 • Letter: A
Question
A protein in the Er is normally converted from EndoDResistant to EndoDSensitive after it is transported to the cis-golgi. An important control for this experiment was their use of a Ts mutant of the same protein that misfolds at the nonpermissive temperature and is never converted from EndoDResistant to EndoDSensitive. What additional ER component must have been inactivated in these cells to enable the EndoDResistant mutant protein to stably accumulate at the nonpermissive temperature and not be eradicated?a) The dislocon was inactivated.
b) Ire1 was inactivated
c) The enzyme that converts Man8 to Man5 was inactivated.
d) The translocon was inactivated.
Explanation / Answer
A protein in the Er is normally converted from EndoDResistant to EndoDSensitive after it is transported to the cis-golgi. An important control for this experiment was their use of a Ts mutant of the same protein that misfolds at the nonpermissive temperature and is never converted from EndoDResistant to EndoDSensitive. What additional ER component must have been inactivated in these cells to enable the EndoDResistant mutant protein to stably accumulate at the nonpermissive temperature and not be eradicated?
a) The dislocon was inactivated.
b) Ire1 was inactivated
c) The enzyme that converts Man8 to Man5 was inactivated.
d) The translocon was inactivated.
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