WC1 is a gene that has been implicated in cancer. Processing of WC1 produces fou
ID: 140588 • Letter: W
Question
WC1 is a gene that has been implicated in cancer. Processing of WC1 produces four different mRNA (A, B, C, and D). In this box-and-whisker plot, the amounts of mRNA expressed by WC1 are shown. On the left axis, the total amount of mRNA expressed is measured (dark grey bars) for normal bone marrow (nBM) and for bone marrow samples from patients with childhood acute myeloid leukemia (chAML). On the right axis, expression levels of the 4 different mRNA forms (represented as ratios of the total) is measured under normal and leukemia cellular conditions. The asterisks () indicate a significant difference between normal and leukemia conditions. wci total mRNA A mRNA B 0.8 3 0.4 0.2 3 0.0 g MRNA D 0 nBM chAML According to this data, what is the role of WC1 in childhood acute myeloid leukemia (chAML)?Explanation / Answer
According to the data, the following conclusions can be drawn:
Numerical summary (only for WC1 total):
Normal Bone marrow (nBM):
Child Acute myeloid leukemia:
Conclusion: From the graph it can be clearly understood that, there is significance correlation of expression of WC1 gene in pathogenesis of childhood acute myeloid leukemia
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