This problem refers to the MN and ABO loci mentioned in class. It also refers to

Question

This problem refers to the MN and ABO loci mentioned in class. It also refers to the Rh locus, which is responsible for the positive/negative part of the blood type. The Rh+ allele is dominant to the Rh- allele at this locus. Select all couples who could be the parents of a child with phenotype MN,AB+ based on the phenotypes at these three loci. If none of these couples could be the parents of this child, select "None of These".

Select one or more:

Mother Type M, A+ and Father Type N, B-

Mother Type MN, AB- and Father Type M, O-

Mother Type MN, B+ and Father Type N, O+

Mother Type MN, O+ and Father Type MN, A-

None of These

I'm struggling because of the MN (vs just M) I think and it's confusing me

Explanation / Answer

The MN blood group is co dominant and once in herited both are expressed. In the ABO blood group system bothe A and B alleles are codominant and can be expressed simultaneously while O/Io is recessive and as given in the question Rh+ is dominant over Rh-. The child’s phenotype is MN, AB+

Thus based on these information we can say that, Option 1 is the correct answer (Mother Type M, A+ and Father Type N, B-).

Mother Type MN, AB- and Father Type M, O- is not the option since the child would be Rh – in this case and Mother Type MN, B+ and Father Type N, O+ will give the child a B or O blood group. In the third option Mother Type MN, O+ and Father Type MN, A- will give the child a A or O blood group not AB blood group as given in the information.

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