ect Question 1 0/1 pts The acetylation of lysines on the histone tails .. .doubl
ID: 141808 • Letter: E
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ect Question 1 0/1 pts The acetylation of lysines on the histone tails .. .double check the book for this one as I think I mis-spoke during the lecture) oosens the chromatin structure because it adds positive charges to the histone can be performed on methylated lysines only after they are first demethylated. is a covalent modification and is thus irreversible. recruits the heterochromatin protein HP1, resulting in the establishment of heterochromatin. is sufficient for the formation of an open chromatin structure.Explanation / Answer
B) Can be performed on methylated lysines only after they are first demethylated is the correct option.
The 'C' terminus of histone consists of lysine and arginine. The C terminus is modified by acetylation, deacetylation, and methylation. Acetylation helps in unwrapping the DNA from the histone so that RNA polymerase is able to access the gene and transcribe it. While adding an acetyl group to the histone tail, the histone becomes more negatively charged. (so that unwrapping of DNA takes place)
Methylation causes an increase in positive charge of histone so that DNA is more tightly wrapped around the histone. Therefore, acetylation of lysine on the histone tail can be performed on methylated lysine only after first demethylated(to unwrap the DNA)
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