Consider a couple, both of whom carry an X-linked recessive allele for a disease

Question

Consider a couple, both of whom carry an X-linked recessive allele for a disease known as Wigout Syndrome (WS), which results in hyper-anxiety under stressful conditions, characterized by hyperventilation. Assume this couple has 4 kids, ages 6, 4, 2, and 1 years old. What is the probability that 2 of their children are males with WS, assuming that WS is only 60% penetrant? Enter a number your answer to 3 decimal places. (Remember that you will need to factor in the different permutations/combinations of kids that could have WS, and the status of the other children. You may want to refer to the Distinguishable Permutations problem.)

Explanation / Answer

If both parents are carriers of the recessive the allele for a disorder likewise here, X-linked Wigout Syndrome(WS) all 4 children with inherited by possibilities of 25% chance of having the recessive disorder,50% chance of being a healthy carrier and 25% chance of being healthy and not have the recessive allele at all. Now in 4 children if two are male and as alleles are X -linked the possibilities like one are healthy and one is affected but the carrier as recessive allele as a male never passes an x-linked trait to a son.so the probability is 0.25 but here the WS is only ^0% penetrant the final probability should be 0.15

Related Questions

Navigate

• Browse (All)
• Browse C
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.