Question: Succinic acid dehydrogenase catalyzes the reaction of succinic acid to

Question

Question: Succinic acid dehydrogenase catalyzes the reaction of succinic acid to fumaric acid. The reaction is inhibited by malonic acid (which Regulation embles succinic acid, but cannot be catalyzed by succinic dehydrogenase). Increasing the ratio of succinic acid to malonic acid reduces the inhibitory effect of malonic acid. Which of the following is correct? A. Succinic acid dehydrogenase is the enzyme and fumaric acid is the substrate. B. Succinic acid dehydrogenase is the enzyme and malonic acid is the substrate. C. Succinic acid is the substrate and fumaric acid is the product. D. Fumaric acid is the enzyme and malonic acid is a noncompetitive inhibitor. E. Malonic acid is the product and fumeric acid is a competitive inhibitor.

Explanation / Answer

When Succinic acid bind with enzyme then following reaction occurs SDH(enzyme)+succinic acid~~~SDH-succinic acid complex-----SDH+fumeric acid(final product)

But when inhibitor bind to enzyme then following reaction takes place

SDH+malonic acid (competitive inhibitor)~~~~SDH-malonic acid complex is formed.

A-Incorrect answer because fumaric acid is not substrate .fumeric acid is product.

B-Incorrect because malonic acid is competitive inhibitor.

C- correct answer because succinic acid is substrate and fumeric acid is product.

D-Incorrect because fumeric acid is product and malonic acid is competitive inhibitor.

E-Incorrect because malonic acid is inhibitor and fumeric acid is product.

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