ect Question 3 0/1 pts Gene X has a point mutation resulting in a premature stop

Question

ect Question 3 0/1 pts Gene X has a point mutation resulting in a premature stop codon in the mRNA Imagine one cell line with this mutant was wild type (for all non Gene X genes) while another had a mutation in the nonsense mediated decay (NMD) pathway in addition to the Gene X mutation. If proteins were extracted from each cell line and a western blot probing for Gene X was performed, what would we expect to see or the western blot? C The Gene X band from both cell lines will be the same size and intensity The Gene X band in the wild type cell will be darker but the same size as the NMD mutant cell line band The Gene X band in the wild type cell will be lighter but the same size as the NMD mutant cell line band. The Gene X band in the wild type cell will be darker but a smaller size compared to the NMD mutant cell line band The Gene X band in the wild type cell will be lighter but a larger size compared to the MD mutant cell Quiz Score: 1 out o MacBoolk

Explanation / Answer

The gene x band in the wild type cell will be lighter but a larger size compared to the NMD mutant cell line because nonsense mutations occur when a premature nonsense or stop codon is introduced in the DNA sequence. When the mutated sequence is translated into a protein, the resulting protein is incomplete and shorter than normal.

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