19. Use the information contained in the following table to answer questions I-I

Question

19. Use the information contained in the following table to answer questions I-I. Phosphate hydrolysis is a reaction where a phosphate group is removed from a molecule. This table shows the energy required to break the phosphate bond Free Energies of Phosphate Hydrolysis Molecule Phosphoenolpyruvate-62 Carbamoyl phosphate kJImol -52 43 Creatine phosphate hosphate -30 20 Glucose-1-PO Glucose-6-PO Glycerol-3-PO -8 1. What is the direction of each of the following reactions when the reactants are initially present in equimolar amounts? Use the data given in the table. a. ATP + creatine>creatine phosphate+ ADP b. ATP+ glycerol>glycerol-3-POs+ ADP c. ATP+ pyruvate phosphoenolpyruvate+ADP d. ATP +glucoseglucose-6-PO4+ADP Il. Calculate the standard free-energy change for the isomerization of glucose-6-POs to glucose-1-PO4. 4 0

Explanation / Answer

I. The free energy of hydrolysis for all the molecule shows a negative standard Gibbs free energy, it simply means that all the reactions are spontaneous reactions. Therefore all the reactions (a),(b),(c), (d) will be spontaneously driven in the direction where the actual molecule in question hydrolyse to generate ATP.

II. Glucose 6-P + ADP ---------> Glucose + ATP (delta G= -13KJ/mol)

whereas Glucose +ATP -------------> Glucose 1-P +ADP (delta G= +20 KJ/mol)

Therefore, standard free energy change of isomerization will be (-13+20)= +7KJ/mol

III. This is a direct question, answer to this question can be directly found on the table.

Standard Gibbs free energy cahnge for the reaction is -43 KJ/mol.

NOTE: Please feel free to comment on the answer if you need further explanation. Thank you.

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