Please help me answer this one Please help me answer this one A 22-year-old Cauc

Question

Please help me answer this one Please help me answer this one A 22-year-old Caucasian woman of Italian heritage had been told that she was slightly anemic and had been treated with iron periodically throughout her life. She was a student in a clinical laboratory science program and had a CBC performed as a part of a hematology class. Laboratory values are as follows: REFERENCE RANGE Hemoglobin 11.0 g/dL 11.7-15.7 g/dL Hematocrit 34% RBC MCV MCHC RDW 35-47% 5.8 x 1012/L 3.8-5.2x 101/L 59.4fL 80-100 f 31.9% 14.2% 32-36% 115-145% From these values, the hematology instructor suspected an inherited disorder instead of iron deficiency and suggested that the student contact her physician for further testing. A hemoglobin electrophoresis revealed slightly increased amounts of hemoglobins F and A2, which were subsequently quantitated to reveal hemoglobin F of 3.2% and hemoglobin A2 of 4.2%. Iron studies were normal. QUESTIONS 1. What is the most probable disorder? 2. What CBC values caused the instructor to suggest further testing? 3. Why is it important for this disorder to be correctly diagnosed?

Explanation / Answer

1) here by oserving the slightly increased amounts of haemoglobin F and A2 it indicates that inherited disorder BETA THALASSEMIA

2)normal iron deficiency anaemic conditions shows RBC count is generally low but CBT profile shows incresed amount of RBC and also slightly decrease in the MCHC value,marked decrese in the MCV values indicates further testing

3)it is important to diagnise wether it is iron deficiency anaemia or inherited disorder like beta thalassemia because in case of betathalamassia triat there is no significant increase in haemoblobin amount eventhough iron treatment and also misdiagnosis leads to further complications for example it is inherited to offsprings through one of the parents

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