You discover a new dominant mutation that causes memory loss in middle aged adul

Question

You discover a new dominant mutation that causes memory loss in middle aged adults. You identify a genetic variant on chromosome 4 that co-segregates with the disease within a family. The pedigree shows each individual's genotype at that marker (the two alleles are 1 and 2) and whether they have the disease (black symbols).

A) Based on the pattern of inheritance in the pedigree, what is the most likely genotype for individual I1 (assume he is heterozygous for the disease causing mutation). D stands for the disease mutation, and d stands for the recessive allele.

B) Based on the phase of alleles on chromosomes in generation II, is there any evidence of recombination among the eight offspring in generation III? Choose the correct explanation.

Please explain how you solve this.

You discover a new dominant mutation that causes memory loss in middle aged adults. You identify a genetic variant on chromosome 4 that co-segregates with the disease within a family. The pedigree shows each individual's genotype at that marker (the two alleles are 1 and 2) and whether they have the disease (black symbols) 1,2 2,2 Part A Based on the pattern of inheritance in the pedigree, what is the most likely genotype for individual I-1 (assume he is heterozygous for the disease causing mutation). D stands for the disease mutation, and d stands for the recessive allele. 1,2 2,2 1,2 1,2 2,2 1,2 2,2 2,2 1,2 2, 2 d1ID2 D1/d2 Both of the options above are equally likely Submit Request Answer Part B Based on the phase of alleles on chromosomes in generation ls there any evidence of recombination among the eight of Spring n generation III? Choose the correct explanation. Yes, III-3, -5, and .8 are recombinants. Yes, II-1, -2, 111-4, and III-7, are recombinants. Yes, III-6 is a recombinant. No, there is no evidence. Submit st Answer

Explanation / Answer

Part A-D1/d2

Part B-yess |||6 is a recombinant because it is different from parent one allele (1,2 ) that will causes mutation.

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