1. Here\'s a pedigree showing a family in which a disease is inherited in a Mend

Question

1. Here's a pedigree showing a family in which a disease is inherited in a Mendelian autosomal manner. The disease is either dominant or recessive. We will denote the alleles at the disease locus and g, and stipulate that individuals with the qg genotype are affected with the disease and 00 individuals are unaffected. Assume that new mutation plays no role. a. Is the phenotype dominant or recessive? Write the genotype for these individuals. If their genotypes are uncertain, specify the probability of each possible genotype. b. Generation I individual 1 1 2 3 4 c. Generation II individual 2 1 2 VI d. Generation II individual 3 e. Generation V, individual 4

Explanation / Answer

1. a. The disease is autosomal recessive.

b. Qq ( both the parents are heterozygous in autosomal recessive disease)

c. qq (It is the affected inividual)

d. QQ or Qq

e. qQ

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