The following combinations are WRONG: 1, 2, 3 2, 3, 5 1, 4, 5 Pay particular att
ID: 146478 • Letter: T
Question
The following combinations are WRONG:
1, 2, 3
2, 3, 5
1, 4, 5
Pay particular attention here to the way in which the structure of a molecule influences its function You previously learned how the compound DNP uncouples NADH oxidation from ATP synthesis by disrupting the H+ gradient across the inner mitochondrial membrane. The diagram below depicts DNP in its hydrogen-ion- bound and unbound forms. NO NO, NO, NO, Copyrigt The Pdet and Fellows f Harard Colle Note that while the oxygen atom on this molecule is depicted with a negative charge, the unique chemical structure of DNP causes this negative charge to be distributed throughout the molecule, thus giving the molecule some nonpolar properties. Which of the following features of the mitochondrial inner membrane are important for the normal function of mitochondria, and for the effects of DNP on their function? (select three answers) they are impermeable to DNP when it is n they are permeable to DNP when it is not bound to H+ they are impermeable to DNP when it is bound to H+ they are permeable to DNP when it is bound to H they are impermeable to free H* they are permeable to free H ot bound to HExplanation / Answer
The answer is 2,4,5
The inner membrane is permeable to DNP when it is not bound to H+ . negatively charged form of DNP can cross the inner membrane in to the matrix as its unique structure ( the electron withdrawal by nitro groups at ortho and para position of benzene ring ) allows the negative charge to distribute equally and act as a neutral complex.
They are permeable to DNP when bound to protons . deprotonated DNP picks one proton from inter membrane space ,as concentration of H+ ion is relatively more there ,and neutral DNP passes across the inner membrane and releases the proton as proton concentration is less at matrix . There by DNP alters the proton gradient and inhibit ATPproduction . so it is also known as chemical uncoupler of oxidative phosphorylation .
They are impermeable to free protons . inner membrane of mitochondria consists of phospholipid bilayer and outer hydrophobic head of lipid portion is impermeable to charged molecules . but there are lots of transport proteins for ion transportation across the membrane . As for H+ ion it is ATP synthase or F1F0 ATP synthase.
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