QUESTION 3 1 point possible (graded) Hemophilia A is a condition characterized b

Question

QUESTION 3 1 point possible (graded) Hemophilia A is a condition characterized by an inability of the blood to clot, which can cause profuse bleeding even after a minor injury, It is often caused by recessive pathogenic variants in the X-linked FVIllI gene, which encodes factor VIll, a protein produced in the liver and released into the bloodstream to facilitate blood clotting. There are many possible pathogenic variants in the FVill gene, which reduce the function or level of factor Vill. In some cases, females can be manifesting carriers of this disorder, which means that individuals O heterozygous; may have defective blood clotting homozygous; may have defective blood clotting heterozygous, all have normal blood clotting homozygous; all have normal blood clotting O O

Explanation / Answer

Haemophilia is an X-linked recessive disease which is caused due to the defect in factor VIII.

Female has two X-chromosomes. So if the female is the carrier that means that She has one defective chromosome and one normal chromosome. Since haemophilia is a recessive disease so the female should have both chromosomes which have defective in order to have the defect in blood clotting.

So carrier female is heterozygous and has normal blood clotting.

So answer is option C

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