The sickle cell allele is a recessive allele that results in sickle cell disease

Question

The sickle cell allele is a recessive allele that results in sickle cell disease when it is homozygous. In a heterozygous state, the carrier is immune to malaria. Two people who are both carriers of the sickle cell allele (Hb A Hb S) want to have children. They live in an area where malaria is transmitted by mosquitos. They come to you for advice. Which of the following would be a true statement you could tell them?

None of their children could have sickle cell disease, and they would have a 50% chance of being immune to malaria.

They could have a child with sickle cell disease, but having a child immune to malaria is twice as likely.

All of their children will be immune to malaria.

Any child would be certain to have sickle cell disease.

None of their children could have sickle cell disease, and they would have a 50% chance of being immune to malaria.

They could have a child with sickle cell disease, but having a child immune to malaria is twice as likely.

All of their children will be immune to malaria.

Any child would be certain to have sickle cell disease.

Explanation / Answer

Hb S cause sickle cell anaemia and HB A is normal haemoglobin hence answer is none of their children could have sickle cell disease and would have 50%change of being immune to malaria.

As the two type and hb form children with sickle cell trait and not disease and give partial immunity from malaria.

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