The sickle cell allele is a recessive allele that results in sickle cell disease
ID: 149521 • Letter: T
Question
The sickle cell allele is a recessive allele that results in sickle cell disease when it is homozygous. In a heterozygous state, the carrier is immune to malaria. Two people who are both carriers of the sickle cell allele (Hb A Hb S) want to have children. They live in an area where malaria is transmitted by mosquitos. They come to you for advice. Which of the following would be a true statement you could tell them?
O All of their children will be immune to malaria. They could have a child with sickle cell disease, but having a child immune to malaria is twice as likely. O Any child would be certain to have sickle cell disease None of their children could have sickle cell disease, and they would have a 50% chance of being immune to malaria.Explanation / Answer
Option B : They could have a children with sicke cell disease, but having a child immune to malarai is twice because plasmodium falciparum and plasmodium vivax their receptor is found on heamoglobin molecule but in case of sickle cell anaemia which is an X linked disorder there is a change in shape of heamoglobin molecule ( sickle shaped) due to which mosquito does not able to recognize its receptor and cant spread malaria.
2. In sickle cell anemia the activity of hemoglobin producing enzyme i.e hemokinase regulated by heme gene increases, due to which carbon monoxide gas releases and CO is potent inhibitor of malaria.
Thats why cell with sickle cell disease is more immune to malaria
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