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) C. c D. a E. g During an action potential the direction ofion flow depends on

ID: 149933 • Letter: #

Question

) C. c D. a E. g During an action potential the direction ofion flow depends on yoltage-gated Na+ or K+ channels the cell's membrane potential (e.g. P values)cleci concentration and electrical gradients pase ge bo a change in passive channel activity to 3 E the cell's permeability to each ion changing in a 'feedforward process 45. Compare the firing pattern between three 'typical textbook' neurons (A, B & C) based on the following inputs at the trigger zone. [AP action potential] Neuron X detects 7 EPSPs of 5 m1V, and 2 IPSPs at 4 mV·S-g. Neuron Y detects 5 EPSPs of 7 mV and 4 IPSPs of 4 mv 35-10 : " dn Neuron? detects 4 EPSPs of 4 m V and 2 IPSP of 6 mV. -a-4 all three fire with X more than Y, which is more than Z & Y fire APs, with X firing more than Y; but Z will not fire. only Z fires; X and Y do not fire APs will fire APs, but neither Y nor Z fire APs X fires more than Y or Z which have the same frequency Dexamethasone is a drug used to suppress the secretion of ACTH from the anterior pituitary gland. Two patients with hypersecretion of cortisol are given dexamethasone. nika's cortisol secretion level falls to normal after the medication, but Bonnie's cortisol ecretion remains elevated. Based on this data which statement (s) is/are CORRECT? A. Anika and Bonnie both have primary hypercortisolism B. Anika has primary hypercortisolism CBonnie has primary hypercortisolism D. Anika has primary hypocortisolism E. C and D CRH ACTP Page 8, v3 Corhisol

Explanation / Answer

Answer 46 : Dexamethasone is a glucocorticoid and simulates the effects of cortisol, including negative feedback on the pituitary gland. When dexamethasone is administered and a blood sample is tested, elevated cortisol levels would be indicative of Cushing's syndrome because an ectopic source of cortisol or ACTH (such as adrenal adenoma) exists which is not inhibited by the dexamethasone.