81105 Homework #2 (based on Ch. 2 and 3) Instructor: Cabrera 8. During your summ

Question

81105 Homework #2 (based on Ch. 2 and 3) Instructor: Cabrera 8. During your summer and mutations in this gene research, you identified a gene that is expressed in the Intestinal cells of mice are associated with Crohn's disease. Further analysis reveals... with 1) That the coding sequence of the gene is the same in affected and wild-type (normal) mice 2) While transcription of the gene is normal, there is mice relative to that in the wild-type mice. much less mature mRNA produced in the affected 3) The intestinal cells of the affected mice show no detectable protein unlike the wild-type mice. By considering the steps in eukaryotic gene expression, indicate the absence of which stepls) may explain the differences that you have observed between the affected and wild-type mice. [4 pts 9. Indicate whether the following statements are true or false. If a statement is false, explain why it is false. [12 pts total 9a. Each strand of DNA contains all the information needed to create a new double-stranded DNA molecule with the same sequence information. [3 pts] 9b. In eukaryotes, promoter recognition is mediated by the protein Sigma factor that associates with RNA polymerase.[3 pts 9c. Alternative splicing allows different genes to produce the same protein in eukaryotes. [3 pts] 6

Explanation / Answer

9a) True - this tells us about the semiconservative nature of DNA replication .

When the DNA replicates , each of its two strands gets seperated and each one of them can then act as a template to form the new DNA strand .

9b) False .

The sigma factor is present in the bacteria , which are prokaryotes .

These sigma factors are the initiation factors that initiates the binding of RNA polymerase to the promoter .

9c ) False

Alternative splicing , or the differential splicing is the process by which a single gene gives rise to different proteins.

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