Many transcriptional activators are proteins with a DNA-binding domain (DBD) and
ID: 150725 • Letter: M
Question
Many transcriptional activators are proteins with a DNA-binding domain (DBD) and an activation domain (AD). Explain how each domain contributes to transcriptional initiation. Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Not all terms will be used. Reset Help DBD allows the activator o elements,to corectly poaition the elements, to correctly position the protein to interact with the correct gene sequence. promotor coactivators cofactors The allows the activator to interact with other proteins, such as important to the formation of the complex. enhancer preinitiation promoter escape ADExplanation / Answer
Answer:
The DBD allows the activator to bind to promotor elements, to correctly position the protein to interact with the correct gene sequence.
The AD allows the activator to interact with other proteins, such as coactivators, important to the formation of the preinitiation complex
Explanation: Activators has two domain namely DNA-binding domain which facilitates the binding of activator to the promotor of the gene. Once the activator is bound to the promotor, the coactivator binds to the activator at the Activation domain. This is known as transcription-preinitiation complex.
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