There is another melancone-stimulating hormone called -melan tro an Cleavage of

Question

There is another melancone-stimulating hormone called -melan tro an Cleavage of WGSPPK, DSGPYK.MEHFR -melanotropin wth trypsin produces the folown peptide s us free aspartic acid. Part A If you assume maximum sequence similarity between a-melanotropin and B-melanotropin, then what must the sequence of the latter be? (a -melanotropin: Ser-Tyr-Ser- Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val) Drag the appropriate labels to their respective targets so that the maximum sequence similarity to the order of a-melanotropin will be shown. Reset Help MEHFR DSGPYK WGSPPK

Explanation / Answer

As trypsin cleaves the peptide at carboxy site of Arginine (R) or Lysine (K) except either is followed by Proline (P). if proline is at c terminal of lysine or arginine the trypsin doesn't cut the peptide.

as Alpha melanotropin is very similar to beta-melanotropin in sequence, then the possible sequence of beta-melanotropin will be

DSGPYK-MEHFR-WGSPK-D

last amino acid is Aspartic acid as given in the question, will be at last in the sequence of the peptide.

note: the symbol of the hyphen in the answer is representing the cleavage sites for trypsin.

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