compare and contrast the mode of action of these 2 drugs Semprex (Acrivastine) &

Question

compare and contrast the mode of action of these 2 drugs Semprex (Acrivastine) & Ketotifen (how do they work (type of receptors, 2nd messenger, biological action like inhibit/stimulate growth, proliferation, secretion, relaxation, blood vessel constriction etc), where do they work (i.e. type of tissue/cells, ), and refer to any biomarkers (i.e indicators that the drug is prescribed for: increase/decrease blood pressure, heart rate, urine output, pain relief etc), that may indicate the effect of these drugs. LIST THE REFERENCES

Explanation / Answer

Semprex Ketotifen It is a second generation  H1-receptor antagonist antihistamine . It is a first-generation noncompetitive H1-antihistamine and mast cell stabilizer It works by blocking histamine H1 receptors Inhibits degranulation of mast cells and prevents release of histamine from mast cells. It is an analogue of triprolidine which is an H1-receptor antagonist of the alkylamine class. Competitive antagonism blocks the effects of histamine on H1-receptors in the GI tract (but not at H2-receptors), uterus, large blood vessels, and bronchial muscle. Ir inhibits the effects of endogenous substances known to be inflammatory mediators, and thereby exerts antiallergic activity. Ketotifen possesses a powerful and sustained non-competitive histamine (H 1) blocking property. Ketotifen's antihistamine (H 1) effect seems to be distinct from its antiallergic properties. It is given for asthma and as antiinflammatory agent. It is given for asthma and antiinflammatory agent

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