What are the molecular targets of anticancer drugs? The bark of the Pacific yew

Question

What are the molecular targets of anticancer drugs? The bark of the Pacific yew tree (Taxus brevifolia) was the original source of one of the most effective drugs for treating tumors of the breast, lung, and other sites. Taxol, a chemical extracted from this bark, kills actively replicating cells by inhibiting the depolymerization of microtubules Why are microtubules good targets for killing cancerous cells? Aggressive forms of breast cancer are resistant to Taxol chemotherapy. In these cancers, the gene encoding a protein called Stathmin is overexpressed. In normal cells, stathmin is inactivated by phosphorylation at the start of M phase Phosphatases remove these phosphates as the cell transitions from M phase to G_1 What enzyme is likely to be responsible for phosphorylating stathmin during M phase? the cyclin subunit of MPF the tyrosine kinase subunit of MPF the cyclin-dependent kinase subunit of MPF the histidine kinase subunit of MPF

Explanation / Answer

The enzyme to be likely responsible for phosphorylating stachmin at m phase is

THE CYCLIN- DEPENDENT KINASE SUBUNIT OF MPF.

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