What are the molecular targets of anticancer drugs? The bark of the Pacific yew

Question

What are the molecular targets of anticancer drugs? The bark of the Pacific yew tree (Taxus brevifolia) was the original source of one of the most effective drugs for treating tumors of the breast lung, and other sites. Taxol, a chemical extracted from this bark, kills actively replicating cells by inhibiting the depolymerization of microtubules. Why are microtubules good targets for killing cancerous cells? In aggressive forms of breast cancer, the gene encoding a protein called stathmin is overexpressed. Inhibiting expression of the stathmin gene arrests cells in M phase and is being investigated as an alternative therapy tor treating cancer What additional genes could be therapeutic targets that, when inactivated, would arrest cancerous cells in G_1 phase? Select all that apply. genes for MPF gene for G_1 cyclins genes for Rb activity genes for E2F protein none of the above

Explanation / Answer

RB gene codes for the protein called as retinoblastoma protein which function as inhibitor of G1 transition during the cell cycle progression in carcinoma of brest, Colon, lung. RB also controles the cellular differentiation. It exists in an active hypophoshorilated state in quiescent cells and an inactive hyperphoshorylated state in cells passing through the G1 cell cycle transition.

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