Synthesis of the amino acid glutamate can be effected from pyruvate and alanine
ID: 167298 • Letter: S
Question
Synthesis of the amino acid glutamate can be effected from pyruvate and alanine by a metabolic sequence that illustrates the amphibiolic role of the TCA cycle. DEvise such a pathway, assuming the availability of whatever additional enzymes may be needed.
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Synthesis of the amino acid glutamate can be effected from pyruvate and alanine by a metabolic sequence that illustrates the amphibolic role of the TCA cycle. Devise such a pathway, assuming the availability of whatever additional enzymes may be needed. Drag he terms on the left to the appropriate blanks on the right to complete the reactions. Terms can be used once, more than once, or not at a Reset Help acetyl-CoA Pyruvate ADP +Pi ATP H2O. isocitrate Pyruvate CoA-SH +acety-CoA a-ketoglutarate Acetyl-CoA CoA-SH succinate NADH+H+ citrate NAD CO2 NADH H+ NAD alanine glutamate pyruvate H20 oxaloacetate COExplanation / Answer
Pyruvate + CO2. + ATP + H2O Oxaloacetate + ADP + Pi
Pyruvate + CoA - SH + NAD+ Acetyl-CoA + NADH + CO2
Acetyl-CoA + Oxaloacetate + H2O Citrate + CoA – SH
Citrate Isocitrate
Isocitrate + NAD+ Alpha-Ketoglutarate + CO2 + NADH + H+
Alpha-Ketoglutarate + Alanine Glutamate + Pyruvate
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