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Oxidation by hydrogen peroxide can damage DNA. What base is most vulnerable to o

ID: 167805 • Letter: O

Question

Oxidation by hydrogen peroxide can damage DNA. What base is most vulnerable to oxidation damage? _ When the most vulnerable base is oxidized it often becomes 8-oxoguanino (8oxoG). What repair pathway recognizes and repairs this kind of damage? Let's say oxidation produces an 8oxoG and replication occurs before repair occurs. What are the two base pairs that are produced by replication? Note, assume repair still has not happened. Let's say a second round of replication occurs without any repair. What are the tour base-pairs produced? Note, assume repair still has not happened. the mismatch repair pathway uses the presence of _ at positions near the mismatch on the template strand to properly repair mismatch errors. Familial Down Syndrome results from the inheritance of a chromosome with the long arm of chromosome 21 translocated onto chromosome. There is no phenotype associated with the translocation itself. What is a reasonable explanation for why there is no phenotype associated with the translocation? _ Let's say a carrier of the translocated chromosome mates with a wildtype individual, what is the probability that a full-term child born from this couple will have Familial Down Syndrome? See diagram for details on the carrier and its expected gametes. Assume no additional mutations occur.

Explanation / Answer

12 (a)

12 (b)

12 (c)

12 (d)