To shut down a signalling pathway based on a receptor tyrosine kinase, an monocl

Question

To shut down a signalling pathway based on a receptor tyrosine kinase, an monoclonal antibody that targets the hormone receptor on the outside of the cell would be a viable therapeutic approach if: (SELECT ALL THAT APPLY)

A. The antibody binding prevents receptor dimerization and thus keeps the intracellular kinase domains from phosphorylating each other

B. The antibody is administered such that it can easily reach the cell (for example through an IV injection)

C. The antibody bound strongly to albumin, preventing it from reaching its target

Explanation / Answer

A. The monoclonal or mAb acts as therapeutic drug. Its binding prevents receptor dimerization by the following processes:

B. Small molecule drugs are given as oral or intravenous medication while monoclonal antibodies are always administered intravenously because mAb can be destroyed in the digestive system before reaching the cancerous cells. Small molecule drugs have a direct impact on their targets whereas monoclonal antibodies redirect the targets to the immune system for treatment.

C. Monoclonal Anti-Albumin antibody is used in immunofluorescence staining. It can also be used for identification of human serum albumin in several immunochemical assays like ELISA and Western blotting.

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