To shut down a signalling pathway based on a receptor tyrosine kinase, an monocl

ID: 167732 • Letter: T

Question

To shut down a signalling pathway based on a receptor tyrosine kinase, an monoclonal antibody that targets the hormone receptor on the outside of the cell would be a viable therapeutic approach if: (SELECT ALL THAT APPLY)

A. The antibody binding prevents receptor dimerization and thus keeps the intracellular kinase domains from phosphorylating each other

B. The antibody is administered such that it can easily reach the cell (for example through an IV injection)

C. The antibody bound strongly to albumin, preventing it from reaching its target

Explanation / Answer

The correct answer is ‘A’. if receptor dimerization is inhibited, further downstream signalling would be affected.

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To shut down a signalling pathway based on a receptor tyrosine kinase, an monocl

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To shut down a signalling pathway based on a receptor tyrosine kinase, an monocl

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