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Consider the pedigree below showing a rare (not commonly found in the population

ID: 168295 • Letter: C

Question

Consider the pedigree below showing a rare (not commonly found in the population) X-linked recessive trait. Assume no spontaneous mutations in this family and 100% penetrance. In the first generation, the man is unaffected and the woman is affected. Individuals indicated by letters in subsequent generations may or may not be affected. Choose your answer carefully since you will receive credit only if you select all possible correct answers. Which individuals, if any, should be carriers of this trait, but not effected (100% chance of being carriers)? If none of the individuals has a 100% chance of being a carrier then select "Q". A B C D E F G H I J K L M N O P Q

Explanation / Answer

Answer: When in first generation man is unaffected and woman is affected, assuming no spontaneous mutation and 100% penetrance, C and E must be affected in the subsequent generation.

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