Consider the pedigree below showing a rare (not commonly found in the population

Question

Consider the pedigree below showing a rare (not commonly found in the population) X-linked recessive trait. Assume no spontaneous mutations in this family and 100% penetrance. In the first generation, the man is unaffected and the woman is affected. Individuals indicated by letters in subsequent generations may or may not be affected. Choose your answer(s) carefully since you will receive credit only if you select all possible correct answers. Select all individuals, if any. who have a 1/2 chance of being carriers of this trait. If none of the individuals have a 1/2 chance of being a carrier, then select "Q". A B C D E F G H I J K L M N O P Q

Explanation / Answer

Answer:

In X-linked inheritance, only females can act as carriers while males can either be affected or normal.

Females B and D are 100% carriers. Since the male E is affected, females K and M will be 100% carriers.

Female P will have a 50% chance to be a carrier since her father (J) is normal while mother (K) is a carrier.

Similarly, female H will have 50% chance of being a carrier since the father (A) is normal while the mother (B) is a carrier.

So, only individuals H and P will have 1/2 (50%) chance of being a carrier.

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