Consider the pedigree below showing a rare (not commonly found in the population

Question

Consider the pedigree below showing a rare (not commonly found in the population) X-linked recessive trait. Assume no spontaneous mutations in this family and 100% penetrance. In the first generation, the man is unaffected and the woman is affected. Individuals indicated by letters in subsequent generations may or may not be affected. Choose your answer(s) carefully since you will receive credit only if you select all possible correct answers. If individual A also showed the trait (was shaded in), which of this children would for sure be affected? If none of the individuals would be affected for sure select "Q". A B C D E F G H I J K L M N O P Q

Explanation / Answer

X^c --------------- X- LINKED RECESSIVE allele

X --------------- normal allele

One X- LINKED RECESSIVE allele is enough for expression in male

Female require double dose of X- LINKED RECESSIVE alleles --------- for expression in females

INDIVIDUAL A----------AFFECED WITH X- LINKED RECESSIVE TRAIT --------GENOTYPE-----X^c Y

INDIVIDUAL B-------------------CARRIER------------------------GENOTYPE-----X^c X

                      INDIVIDUAL A          X        INDIVIDUAL B

X^c

Y

X^c

X^c X^c

AFFECTED FEMALE

X^c Y

AFFECTED MALE

X

X^c X

NORMAL CARRIER FEMALE

Y X NORMAL MALE

GENOTYPE

G & I

50% RISK OF RECESSIVE GENETIC DISORDER

WITH

X^c Y -------AFFECTED MALE

OR

Y X -----------NORMAL MALE

H

50% RISK OF RECESSIVE GENETIC DISORDER

X^c X^c----------AFFECTED FEMALE

X^c X ---------NORMAL CARRIER FEMALE

X^c

Y

X^c

X^c X^c

AFFECTED FEMALE

X^c Y

AFFECTED MALE

X

X^c X

NORMAL CARRIER FEMALE

Y X NORMAL MALE

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