What would happen to the ATP yield of cellular respiration if the transporter th

Question

What would happen to the ATP yield of cellular respiration if the transporter that imports pyruvate into the mitochondria worked only at 10% if its normal capacity? Detail the defect of this on ATP production for all three phases of glucose breakdown. What would happen to the ATP yield of cellular respiration if the transporter that imports pyruvate into the mitochondria worked only at 10% if its normal capacity? Detail the defect of this on ATP production for all three phases of glucose breakdown.

Explanation / Answer

ATP yield in cellular respiration in normal transporter of pyruvate:

Gradual oxidation of glucose during cellular respiration can produce usable energy. The breakdown of glucose can produce ATP in following steps.

STEP 1: Glycolysis 6 ATP Produced.

STEP 2: Oxidative posporilation 6 ATP Produced.

STEP 3: Krebs cycle or citric acid cycle 24 ATP Produced.

ATP yield in cellular respiration in 10 % of pyruvate transport:

Condition A : (Fat as fuel)

ATP yield is normal if the mitochondria can utilize fatty acids as precursor. During the synthesis of ATP mitochondria can utilize both pyruvate and fatty acids as fuel. all the three phases of glucose breakdown is normal in this.

Condition B : (Pyruvate as fuel)

In this case the ATP yield is completely depends on pyruvate. Due to this reason if the pyruvate transported is less, then the ATP production also become less.

In this condition step is normal because it occurs in cytoplasm. Remaining step 2 and 3 became slow due to the insufficient fuel (pyruvate) supply.

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