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Question 21 Why are spent fuel rods highly radioactive? What does a cancer slope

ID: 1710524 • Letter: Q

Question

Question 21

Why are spent fuel rods highly radioactive? What does a cancer slope factor represent? 20 additional cancers were observed over course of peoples' lifetime in a population of 10 million. What is the ILCR for that cancer? Is cancer a "chronic" disease outcome, or an "acute" disease outcome, and why? If the ILCR exactly doubles as the dose doubles, does this mean the toxicology model is near no threshold" or "linear with threshold". Why? The dose of carcinogen A to a population is is 1 mg/kg-day. The cancer slope factor is 0.0005 (mg/kg-day) What is the ILCR? Is the above ILCR considered a generally acceptable level of risk? Why/Why not? For the preceding problem, if the population size is 500,000, how many additional cancers will there be over the course of the lifetimes of the people in that population? If you took a million people and bruised their hand each in exactly the same way, is it possible that you would induce a few cases of some kind of cancer by so doing? Why/why not. Let's say you are reading about a study of the effects of hexavalent chromium on the organism daphnia, where the study was exposing the organisms to 1 mg/L for 3 days and observing their ability to swim. Are you reading about a chronic endpoint or an acute endpoint?

Explanation / Answer

The ILCR value is 5 x 10-4. An ILCR of 1.0 X 10-4 is considered high as it means that 1 in every 10,000 is prone to cancer disease. Thus, an ILCR of 5 x 10-4 means risk of 5 in 10,000 indicating very high risk.

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