Question 23 Deposition: Duke Energy and Gov. McCrory ignored cancer-risk estimat

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Question 23

Deposition: Duke Energy and Gov. McCrory ignored cancer-risk estimate for polluted well water approved by CDC Winston Salem Journal - June 9, 2016 http://www.iournalnow.com/news/local/deposition-duke-energy-and-gov-mccrorv-ignored-cancer-risk-estimate/article 85fce9cb-22cl-538d-ab8d-2689942cd98f.html ... "The screening level must carry a lifetime cancer risk of 1 in 1 million. Ideally, water should contain no hexavalent chromium, environmental advocates say, but the level of 0.07 parts per billion is considered health-protective. Well owners such as Amy Brown in Belmont, near Duke Energy's Allen power plant, would face a lifetime cancer risk of 1 in 1 million if the concentration of hexavalent chromium met that level. The chances would be even slimmer if the concentration were smaller" To make the calculations, what two values are needed to calculate incremental risk? ________ You have to drink the water to get exposed. So, what is being assumed about that process, and for how long? ___________________ You work in a building for 10 years and develop asthma. Is this a chronic or acute effect? 100 additional cancers of some type were observed over course of peoples' lifetime in a population of 5 million. Everyone had the same exposure to the causative chemical, in units of mg/kg-day. What is the ILCR for the chemical and that cancer? The NOAEL concentration for a chemical in air for chronic exposure for some endpoint is 0.1 mu g/m^3. What will be selected as the reference dose concentration for inhalation? For the same chemical in the preceding problem, the measured exposure concentration is 0.05 mu g/m^3. What is the Hazard Quotient?

Explanation / Answer

NOAEL is the highest level of the dose concentration that can be taken for inhalation only when they are calculated experimentally. For chronic endpoint of 0.1 microgram/m3 it is seen that there may be uncertainty about the calculation of the concentration, as a result a uncertainty factor ( may be like 10 times) must be applied which may act as a reference dose of concentration for the inhalation.

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