27. A partial peptide sequence for the wild type and four mutant alleles of gene

Question

27. A partial peptide sequence for the wild type and four mutant alleles of gene, PETI,are shown below. Each mutant was caused by a single point mutation. Using the amino acid sequence of the wild type and the four mutants, deduce the exact DNA sequence of the coding strand of the wild-type allele. 1. Wild type: met ile arg met asp lys trp... 2. Mutant 1 met ile gin asn gly 3. Mutant 2: met ile arg met gly lys trp... 4. Mutant 3 met ile ser met asp ys trp 5. Mutant 4 met ile arg met asp asn val A) ATG ATT CGA ATG GAC AAA TGG B) ATG ATC AGA ATG GAT AAG TGG C) ATG ATC AGG ATG GAT AAG TGG D) ATG ATA GCG ATG GAC AAA TGG E) ATG ATC AGA ATG GAC AAA TGG

Explanation / Answer

The nucleotide sequence for the protein sequence is

ATG ATT CGA ATG GAC AAA TGG

So the answer is A

This is according to the table-

Amino Acid

DNA codons

Isoleucine

I

ATT, ATC, ATA

L

V

F

TGT, TGC

A

GCT, GCC, GCA, GCG

G

P

T

Tyrosine  

H

E

Aspartic acid

D

K

R

Amino Acid

SLC

DNA codons

Isoleucine

I

ATT, ATC, ATA

Leucine  

L

CTT, CTC, CTA, CTG, TTA, TTG Valine

V

GTT, GTC, GTA, GTG Phenylalanine  

F

TTT, TTC Methionine M ATG Cysteine C

TGT, TGC

Alanine      

A

GCT, GCC, GCA, GCG

Glycine  

G

GGT, GGC, GGA, GGG Proline      

P

CCT, CCC, CCA, CCG Threonine  

T

ACT, ACC, ACA, ACG Serine        S TCT, TCC, TCA, TCG, AGT, AGC

Tyrosine  

Y TAT, TAC Tryptophan   W TGG Glutamine   Q CAA, CAG Asparagine   N AAT, AAC Histidine

H

CAT, CAC Glutamic acid  

E

GAA, GAG

Aspartic acid

D

GAT, GAC Lysine       

K

AAA, AAG Arginine  

R

CGT, CGC, CGA, CGG, AGA, AGG Stop codons Stop TAA, TAG, TGA

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