Two genes, along with their promoters and regulatory elements are represented be

Question

Two genes, along with their promoters and regulatory elements are represented below. The//indicates a distance of more than 1000 nucleotides separating the promoters from the regulatory elements. a. Circle the correct answer in brackets and explain your answer below. If elements A-E provide positive control, then the control elements for both genes are considered [silencer/enhancer/promoter-proximal] elements. b. Assume that element A is a silencer and elements B, C and D are enhancers. Which combination of regulators will cause a high level of expression for the fantasia gene? Select all that apply. a. A, B, C, D b. A and C c. B and D d. A and D e. C and D c. Assume that element A is a silencer and elements B, C and D are enhancers. Which combination of regulators will cause a high level of expression for the imagining gene? Select all that apply. a. A, B, C, D b. A and B c. B and D d. A and D e. C and D d. If element A is a silencer and element B is an enhancer, what histone marks would you find associated with elements A and B (in that order)? a. H3K4Me and H3K4Me b. H3K4Me and H3K9Me c. H3K9Me and H3K4Me d. H3K9Me and H3K9me

Explanation / Answer

a) If the elements A-E are postive regulators then, these are considered as enhancers. Had they been, negative regulator of the gene, i.e if these elements repressed the trascription of gene, these would be cosidered as silencer.

b)SInce A is silencer, hence it will repress the gene transcription while B, C,D being enhancers will promote gene transcription. Therefore option c. B and D and e. C and D are correct.

c)Option c. B and D and e. C and D are correct. Same reason as in part b)

d) Methylation of H3K4 leads to gene transcription, hence associated with enhancer i.e element B whereas methylation of H3K9 leads to gene repression, hence associated with silencer i.e element A. Therefore, option c.H3K9Me and H3K4Me is correct.

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