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In the late 1980s, Robert Weinberg isolated DNA from bladder cancer cells and us

ID: 172941 • Letter: I

Question

In the late 1980s, Robert Weinberg isolated DNA from bladder cancer cells and used this to transfect normal mouse fibroblasts. Which of the following statements is NOT true of this experiment? Altered forms of oncogenes already present in humans contribute to tumorigenesis. Sequence analysis of the transforming gene H-ras was found to contain multiple mutations. The transforming gene was nearly identical with the oncogene derived from Harvey rat sarcoma virus, known as H-ras The DNA recovered from transformed mouse cells contained human sequences.

Explanation / Answer

b) Sequence analysis of the transforming gene H-ras was found to contain multiple mutations

No multiple mutations only a single mutation in the twelfth codon as compared to its counterpart c-ras

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