A) What question, in terms of population genetics, was the CDC survey designed t

Question

A) What question, in terms of population genetics, was the CDC survey designed to answer?

B) What was the independent variable?

C) What was the dependent variable?

D) For the purpose of statistical comparison, which populations would serve as negative controls?

E) What are the frequencies of the wild-type (p = ?) and mutant (q = ?S) alleles in the Black population?

F) What percent of the Black population is: (A) homozygous dominant, (B) SCT, and (C) SCD?

G) What are the frequencies of the wild-type (p = ?) and mutant (q = ?S) alleles in the Hispanic population?

H) What percent of the Hispanic population is/has: (A) normal, (B) SCT, and (C) SCD?

I) In which ethnic population do SCT and SCT occur with the highest frequency?

Case Study (Questions #9-#21): The Centers for Disease Control and Prevention (CDC) conducted a survey of state departments of health records to investigate the frequency of sickie cell urar Tanu sickle disease (SCD) in the U.S. population. All ethnic groups with the potential to inherit SCD are tested at birth, and results are reported to the state departments of health. The results of the survey are given in Table 1. Use the data in Table 1 to answer the following questions. SCT occurs when a single copy of the gene encoding the chain of hemoglobin (Hgb) is inherited. Heterozygous individuals (BBS) do not exhibit pathological signs or symptoms, but do show an increased resistance to the lethal effects of malaria infection. SCD occurs when two copies of the gene encoding the BS chain of Hgb are inherited. Homozygous individuals (BSBS) do exhibit pathological signs and symptoms. SCD is a lethal condition that may result in death before the affected individual reaches reproductive age. The alleles are inherited in a Mendelian fashion and exhibit a codominant relationship Table 1: Frequencies of SCTand SCD in the US Population by Ethnicity. Asian Baci White Hispanic 100 30% 98% 100% Normal none 1 in 62 none SCT SCID none 1 in 333 1 in 16,665 none

Explanation / Answer

A. The study is aimed at determination of the genotype frequency and allele frequency ( or prevalance of the sickle cell alleles) in the U.S. population

B. Independent variable: Ethnic group

C. Dependent variable: Sickle cell trait

D. Asians and White population serve as negative controls as the incidence of SCT is zero in these population.

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