Consider the following biochemical pathway, involving 6 enzymes (e1-e6) leading
ID: 174277 • Letter: C
Question
Consider the following biochemical pathway, involving 6 enzymes (e1-e6) leading to production of compound H.
A ----e1----> B ---e2----> C-------->
----e5-----> G -----e6----> H
D ----e3----> E ---e4----> F-------->
e1, e3, and e5 are allosteric enzymes whereas the rest of the enzymes in the pathway are classic Michaelis-Menton enzymes.
also, note that from compound C and compound F, the pathway combines to enzyme e5 and to compound G.
1. compound A is a homotropic activator. Which enzyme does it activate?
A. e1
B. e2
C. e3
D. e4
E. e5
F. e6
2. How does the homotropic activator/ Compound A interact with the enzyme you pickedi n the previous question?
A. it binds to the active site of the enzyme
B. it increases the fraction of enzyme molecules that are in the T state
C. it decreases the binding affinity of the enzyme for its substrate
D. it increases the Vmax of the enzyme
E. it decreases the Vmax of the enzyme
3. you ahve found that both compounds F and H are heterotropic inhibitors of a particular enzyme in this pathway. which enzyme is this likley to be?
A. e1
B. e2
C. e3
D. e4
E. e5
F. e6
4. how do the heterotrophic inhibitors F and H interact with the enzyme you picked in the previous question?
A. they bind to the active site of the enzyme
B. they increases the fraction of enzyme molecules that are in the T state
C. they do not change the binding affinity of the enzyme for its substrate
D. they increase the Vmax of the enzyme
E. they decrease the Vmax of the enzyme
5. compound C is a heterotropic activator of a particular enzyme in this pathway. which enzyme is likely to be heterotropically activated by compound C?
A. e1
B. e2
C. e3
D. e4
E. e5
F. e6
6. how does the hetrotropic activator/ Compound C interact with the enzyme you pickedi in the previous question?
A. it binds to the active site of the enzyme
B. it increases the fraction of enzyme molecules that are in the T state
C. it increases the binding affinity of the enzyme for its substrate
D. it increases the Vmax of the enzyme
E. it decreases the Vmax of the enzyme
Explanation / Answer
1). A). e1
The homotropic activators are the self-activators, they bond to the substrate cooperatively. It activates the immediate enzyme associated with the production of the product B.
2). A. it binds to the active site of the enzyme
The allosteric activator binds to the active site of the enzyme and increases its substrate binding affinity.
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