You are interested in how cyclic-AMP-dependent protein kinase A (PKA) functions

Question

You are interested in how cyclic-AMP-dependent protein kinase A (PKA) functions to affect learning and memory, and you decide to study its function in the brain. It is known that, in the cells you are studying, PKA works via a signal transduction pathway like the one depicted in the figure below. Furthermore, it is also known that activated PKA phosphorylates the transcriptional regulator called Nerd that then activates transcription of the gene Brainy. For each situation described below what would be the affect be on Brainy transcription? a mutation in the Nerd gene that produces a protein that cannot be phosphorylated by PKA a mutation in the nuclear import sequence of PKA from PPKKKRKV to PPAAAAAV a mutation in the gene that encodes cAMP phosphodiesterase that makes the enzyme inactive a mutation in the gene that encodes adenylyl cyclase that renders the enzyme unable to interact with the a subunit of the G protein

Explanation / Answer

d) Inactivation of G protein will lead to inactivation of the brain gene transcription. If adenylase cyclase is not formed than cAMP is not formed and hence no further downstream process will be activated.

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