When studying Ebola-specific immune responses, researchers isolated numerous lym

Question

When studying Ebola-specific immune responses, researchers isolated numerous lymphocyte clones from several Ebola-infection survivors. One of these clones was named SurvEb8. SurvEb8 lymphocytes produced cytokines when stimulated with a synthetic, Ebola- derived peptide (EboP, whose amino acid sequence was MIFGAVWDSTKHQ) presented by autologous dendritic cells (SE8-DCs). In contrast, EboP failed to stimulate the SurvEb8 clone (i.e., no cytokines were produced) when allogeneic TA1-DCs [i.e., DCs isolated from a genetically unrelated, healthy, control individual immunized with tetanus toxoid antigens (Tet Ag)] were used as antigen-presenting cells. Nevertheless, when loaded with Tet Ag, these TA1-DCs strongly stimulated autologous T cells – i.e., T cells isolated from the control, Tet Ag-immunized individual. SE8-DCs loaded with a synthetic peptide 1 (SP1, whose amino acid sequence was MIEGAVYDSTKHQ) also stimulated SurvEb8 lymphocytes. However, the same SE8-DCs loaded with SP2 (MIEGAVYDSTPHQ) or SP3 (MIFGAVYDSTLHQ) did not stimulate SurvEb8 lymphocytes. These experiments were repeated several times, each time yielding very similar experimental data.

From these results, one can conclude that [complete the sentence and assess (based on your immunology knowledge) the resulting statements (1-55) as either factually correct (true) or incorrect (false)]:
1. the SurvEb8 may be a clone derived from typical TH1 lymphocytes.

2. the SurvEb8 cannot be a clone derived from typical TH1 lymphocytes. 3. the SurvEb8 may be a clone derived from typical TH2 lymphocytes.
4. the SurvEb8 cannot be a clone derived from typical TH2 lymphocytes. 5. the SurvEb8 may be a clone derived from typical TH17 lymphocytes.
6. the SurvEb8 cannot be a clone derived from typical TH17 lymphocytes. 7. the SurvEb8 may be a clone derived from typical TFH lymphocytes.

8. the SurvEb8 cannot be a clone derived from typical TFH lymphocytes.
9. the SurvEb8 may be a clone derived from typical TREG lymphocytes.
10. the SurvEb8 cannot be a clone derived from typical TREG lymphocytes.
11. the SurvEb8 may be a clone derived from typical ab cytotoxic T lymphocytes (CTLs). 12. the SurvEb8 cannot be a clone derived from typical ab CTLs.

13. the SurvEb8 may be a clone derived from typical NK cells.
14. the SurvEb8 cannot be a clone derived from typical NK cells.
15. the SurvEb8 may be a clone derived from typical B1 lymphocytes. 16. the SurvEb8 cannot be a clone derived from typical B1 lymphocytes

17. the SurvEb8 may be a clone derived from typical B2 lymphocytes.

18. the SurvEb8 cannot be a clone derived from typical B2 lymphocytes.
19. the SurvEb8 may be a clone derived from marginal zone B lymphocytes.
20. the SurvEb8 cannot be a clone derived from marginal zone B lymphocytes.
21. the SurvEb8 cells are likely to be CD4-positive.
22. the SurvEb8 cells are unlikely to be CD4-positive.
23. the SurvEb8 cells are likely to be CD8-positive.
24. the SurvEb8 cells are unlikely to be CD8-positive.
25. the SurvEb8 cells may be FOXP3-positive.
26. the SurvEb8 cells cannot be FOXP3-positive.
27. the SurvEb8 cells may be able to mediate ADCC.
28. the SurvEb8 cells may not be able to mediate ADCC.
29. the SurvEb8 cells cannot mediate ADCC.
30. the methionine residue is important for the EboP recognition by SurvEb8 cells.
31. the methionine residue is not important for the EboP recognition by SurvEb8 cells.
32. the isoleucine residue is important for the EboP recognition by SurvEb8 cells.
33. the isoleucine residue is not important for the EboP recognition by SurvEb8 cells.
34. the phenylalanine residue is important for the EboP recognition by SurvEb8 cells.
35. the phenylalanine residue is not important for the EboP recognition by SurvEb8 cells. 36. the glycine residue may be important for the EboP recognition by SurvEb8 cells.
37. the glycine residue may not be important for the EboP recognition by SurvEb8 cells. 38. the alanine residue may be important for the EboP recognition by SurvEb8 cells.
39. the alanine residue may not be important for the EboP recognition by SurvEb8 cells. 40. the valine residue may be important for the EboP recognition by SurvEb8 cells.
41. the valine residue may not be important for the EboP recognition by SurvEb8 cells.
42. the tryptophan residue is important for the EboP recognition by SurvEb8 cells.
43. the tryptophan residue is not important for the EboP recognition by SurvEb8 cells.
44. the aspartic acid residue may be important for the EboP recognition by SurvEb8 cells. 45. the aspartic residue may not be important for the EboP recognition by SurvEb8 cells. 46. the serine residue may be important for the EboP recognition by SurvEb8 cells.
47. the serine residue may not be important for the EboP recognition by SurvEb8 cells. 48. the threonine residue is important for the EboP recognition by SurvEb8 cells.
49. the threonine residue is not important for the EboP recognition by SurvEb8 cells.
50. the lysine residue is important for the EboP recognition by SurvEb8 cells.
51. the lysine residue is not important for the EboP recognition by SurvEb8 cells.
52. the histidine residue may be important for the EboP recognition by SurvEb8 cells.
53. the histidine residue may not be important for the EboP recognition by SurvEb8 cells. 54. the glutamine residue may be important for the EboP recognition by SurvEb8 cells.
55. the glutamine residue may not be important for the EboP recognition by SurvEb8 cells.

Explanation / Answer

1. The SurvEb8 may be a clone derived from typical TH1 lymphocytes. Incorrect (false)

2. The SurvEb8 cannot be a clone derived from typical TH1 lymphocytes. Factually correct (true)

3. The SurvEb8 may be a clone derived from typical TH2 lymphocytes. Incorrect (false)
4. The SurvEb8 cannot be a clone derived from typical TH2 lymphocytes. Factually correct (true)

5. The SurvEb8 may be a clone derived from typical TH17 lymphocytes. Incorrect (false)
6. The SurvEb8 cannot be a clone derived from typical TH17 lymphocytes. Factually correct (true)

7. The SurvEb8 may be a clone derived from typical TFH lymphocytes. Incorrect (false)

8. The SurvEb8 cannot be a clone derived from typical TFH lymphocytes. Factually correct (true)
9. The SurvEb8 may be a clone derived from typical TREG lymphocytes. Incorrect (false)
10. The SurvEb8 cannot be a clone derived from typical TREG lymphocytes. Factually correct (true)
11. The SurvEb8 may be a clone derived from typical ab cytotoxic T lymphocytes (CTLs). incorrect (false)

12. The SurvEb8 cannot be a clone derived from typical ab CTLs. factually correct (true)

13. The SurvEb8 may be a clone derived from typical NK cells. Incorrect (false)
14. The SurvEb8 cannot be a clone derived from typical NK cells. Factually correct (true)
15. The SurvEb8 may be a clone derived from typical B1 lymphocytes. Factually correct (true)

16. The SurvEb8 cannot be a clone derived from typical B1 lymphocytes. Incorrect (false)

17. The SurvEb8 may be a clone derived from typical B2 lymphocytes. Factually correct (true)
18. The SurvEb8 cannot be a clone derived from typical B2 lymphocytes. Incorrect (false)
19. The SurvEb8 may be a clone derived from marginal zone B lymphocytes. Incorrect (false)
20. The SurvEb8 cannot be a clone derived from marginal zone B lymphocytes. Factually correct (true).

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