When studying Ebola-specific immune responses, researchers isolated numerous lym

Question

When studying Ebola-specific immune responses, researchers isolated numerous lymphocyte clones from several Ebola-infection survivors. One of these clones was named SurvEb8. SurvEb8 lymphocytes produced cytokines when stimulated with a synthetic, Ebola- derived peptide (EboP, whose amino acid sequence was MIFGAVWDSTKHQ) presented by autologous dendritic cells (SE8-DCs). In contrast, EboP failed to stimulate the SurvEb8 clone (i.e., no cytokines were produced) when allogeneic TA1-DCs [i.e., DCs isolated from a genetically unrelated, healthy, control individual immunized with tetanus toxoid antigens (Tet Ag)] were used as antigen-presenting cells. Nevertheless, when loaded with Tet Ag, these TA1-DCs strongly stimulated autologous T cells – i.e., T cells isolated from the control, Tet Ag-immunized individual. SE8-DCs loaded with a synthetic peptide 1 (SP1, whose amino acid sequence was MIEGAVYDSTKHQ) also stimulated SurvEb8 lymphocytes. However, the same SE8-DCs loaded with SP2 (MIEGAVYDSTPHQ) or SP3 (MIFGAVYDSTLHQ) did not stimulate SurvEb8 lymphocytes. These experiments were repeated several times, each time yielding very similar experimental data.

From these results, one can conclude that [complete the sentence and assess (based on your immunology knowledge) the resulting statements (1-55) as either factually correct (true) or incorrect (false)]:
1. the SurvEb8 may be a clone derived from typical TH1 lymphocytes.

2. the SurvEb8 cannot be a clone derived from typical TH1 lymphocytes.

3. the SurvEb8 may be a clone derived from typical TH2 lymphocytes.
4. the SurvEb8 cannot be a clone derived from typical TH2 lymphocytes.

5. the SurvEb8 may be a clone derived from typical TH17 lymphocytes.
6. the SurvEb8 cannot be a clone derived from typical TH17 lymphocytes.

7. the SurvEb8 may be a clone derived from typical TFH lymphocytes.

8. the SurvEb8 cannot be a clone derived from typical TFH lymphocytes.
9. the SurvEb8 may be a clone derived from typical TREG lymphocytes.
10. the SurvEb8 cannot be a clone derived from typical TREG lymphocytes.
11. the SurvEb8 may be a clone derived from typical ab cytotoxic T lymphocytes (CTLs).

12. the SurvEb8 cannot be a clone derived from typical ab CTLs.

13. the SurvEb8 may be a clone derived from typical NK cells.
14. the SurvEb8 cannot be a clone derived from typical NK cells.
15. the SurvEb8 may be a clone derived from typical B1 lymphocytes.

16. the SurvEb8 cannot be a clone derived from typical B1 lymphocytes.

17. the SurvEb8 may be a clone derived from typical B2 lymphocytes.
18. the SurvEb8 cannot be a clone derived from typical B2 lymphocytes.
19. the SurvEb8 may be a clone derived from marginal zone B lymphocytes.
20. the SurvEb8 cannot be a clone derived from marginal zone B lymphocytes.

Explanation / Answer

1. the SurvEb8 may be a clone derived from typical TH1 lymphocytes. incorrect (false)

2. the SurvEb8 cannot be a clone derived from typical TH1 lymphocytes. factually correct (true)

3. the SurvEb8 may be a clone derived from typical TH2 lymphocytes. incorrect (false)
4. the SurvEb8 cannot be a clone derived from typical TH2 lymphocytes. factually correct (true)

5. the SurvEb8 may be a clone derived from typical TH17 lymphocytes. incorrect (false)
6. the SurvEb8 cannot be a clone derived from typical TH17 lymphocytes. factually correct (true)

7. the SurvEb8 may be a clone derived from typical TFH lymphocytes. incorrect (false)

8. the SurvEb8 cannot be a clone derived from typical TFH lymphocytes. factually correct (true)
9. the SurvEb8 may be a clone derived from typical TREG lymphocytes. incorrect (false)
10. the SurvEb8 cannot be a clone derived from typical TREG lymphocytes. factually correct (true)
11. the SurvEb8 may be a clone derived from typical ab cytotoxic T lymphocytes (CTLs). incorrect (false)

12. the SurvEb8 cannot be a clone derived from typical ab CTLs. factually correct (true)

13. the SurvEb8 may be a clone derived from typical NK cells. incorrect (false)
14. the SurvEb8 cannot be a clone derived from typical NK cells. factually correct (true)
15. the SurvEb8 may be a clone derived from typical B1 lymphocytes. factually correct (true)

16. the SurvEb8 cannot be a clone derived from typical B1 lymphocytes. incorrect (false)

17. the SurvEb8 may be a clone derived from typical B2 lymphocytes. factually correct (true)
18. the SurvEb8 cannot be a clone derived from typical B2 lymphocytes. incorrect (false)
19. the SurvEb8 may be a clone derived from marginal zone B lymphocytes. incorrect (false)
20. the SurvEb8 cannot be a clone derived from marginal zone B lymphocytes. factually correct (true)

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