Question XI. Tumor-associated antigens (TAAs) are antigens present in tumor cell
ID: 175455 • Letter: Q
Question
Question XI. Tumor-associated antigens (TAAs) are antigens present in tumor cells as well as some normal cells, but often expressed at higher levels in tumor cells. TAAs can originate [complete the sentence and assess the resulting statements (146-157) as either factually correct (true) or incorrect (false) in the given context]:
146. from self-proteins to which the immune system is not tolerant.
147. from viral proteins to which the immune system is not tolerant.
148. as the result of mutations in normal genes in the tumor cell that cause changes in amino acid sequence that generate new epitopes.
149. from proteins expressed during embryogenesis that have become deregulated and reactivated transcriptionally.
150. from proteins expressed continuously at high levels in tumor cells, but only expressed at low levels or transiently in normal cells.
151. by the generation of hybrid genes through genetic recombination, with the consequent production of a new protein unique to the tumor cell.
152. from non-contiguous peptides spliced together by peptide bonds in the proteasome.
153. from proteins normally expressed in immunologically privileged sites.
154. from proteins modified by abnormal post-translational processes.
155. from proteins involved in mitosis that are produced at higher concentrations because the cells are continually dividing.
156. by multiple mechanisms and can serve as targets for cancer immunotherapy.
157. by multiple mechanisms and cannot serve as targets for cancer immunotherapy.
Explanation / Answer
146
FALSE
147
TRUE
148
TRUE
149
FALSE
150
FALSE
151
FALSE
152
TRUE
153
FALSE
154
TRUE
155
FALSE
156
FALSE
157
TRUE
146
FALSE
147
TRUE
148
TRUE
149
FALSE
150
FALSE
151
FALSE
152
TRUE
153
FALSE
154
TRUE
155
FALSE
156
FALSE
157
TRUE
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