Question XI. When type I interferons bind to the cellular interferon-/ receptor

Question

Question XI. When type I interferons bind to the cellular interferon-/ receptor (IFNAR), then [complete the sentence and assess each subsequent statement (90-97) as either factually correct (= “true”) or incorrect (= “false”)]:
90. virus cannot enter the cell.
91. virus can enter the cell, but cannot replicate.
92. virus can replicate within the cell, but cannot be released.
93. viral replication takes place as usual.
94. the cell makes enzymes that prevent cell metabolism.
95. the cell is able to kill bacteria.
96. the cell makes enzymes that degrade mRNA and prevent viral protein synthesis.

97. the cell mounts a specific response to a specific virus.

Explanation / Answer

Type I interferons induce an antiviral state in infected cells or activated cells. The activated cells produce intrinsic antiviral factors like RNA - activated protein kinase, Mx proteins, and the 2-5A system. The factors specifically degrade both double stranded and single stranded RNA of the virus, thus preventing them from replication.

90. False - type-I interferons do not interfere with penetration of virus into cells

91. True. the interferon does not inhibit the virus from entering the cell, but degrades its RNA

92. False. Interferon I interfere with virus replication, it does not allow the virus to replicate

93. False. Virus replication is inhibited by lysis of viral RNA

94. False. The virus does not prevent cell metabolism. It induced only antiviral state

95. False. The cells are able to inhibit replication of bacteria, but cannot kill them

96. True

97. False. Antiviral state is not specific to a virus. An activated cell prevents replication of any virus.

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