What kind of information can gene expression profiles produced by DNA microarray

Question

What kind of information can gene expression profiles produced by DNA microarrays provide about the properties of a tumor?

Option A: Certain cancers that appear to be similar by conventional criteria can be divided into subtypes that have different clinical features based on their gene expression profiles.

Option B: The gene-expression profile of an individual patient’s tumor can reveal how aggressive (lethal) the cancer is likely to be.

Option C: The gene-expression profile of an individual patient’s tumor can provide clues as to which type of therapeutic strategy will be most likely to induce tumor regression.

Option D: All of the choices are correct.

Explanation / Answer

Option D: All of the choices are correct.

gene expression profiling is the ability to further classify tumors into subtypes having distinct biological properties and affect prognoses. For example, some diffuse large B-cell lymphomas (DLBCLs) are indistinguishable based on histological methods yet are clinically heterogeneous: 40% of patients respond well and exhibit prolonged survival while the remaining 60% do not. Gene Expression also has the ability for the therapeutic strategy and aggresiveness properties.

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