Sally, a new graduate student at Miracle implanted in a carcinoma into an immuno

Question

Sally, a new graduate student at Miracle implanted in a carcinoma into an immuno-compromised [Nudel] mouse. After treatment with drug 'Tumorbe-gone', she sees a of tumor size. She tells her mentor that the tumors all disappeared. Her mentor tells her that although she is at MU, there hasn't been a miracle there since Dr Wentz-Hunter wrote an all multiple choice test in the 90's Instead the mentor told her to determine if the tumor regression was the result of necrosis or apoptosis. Explain the difference between necrosis and apoptosis Explain a trigger for necrosis and a trigger for apoptosis in carcinomas. How could she determine if it was one or the other? Cancer cells are said to be closer to triggering apoptosis than normal cells. Support this statement with a discussion making certain to discuss procaspases/caspases. For sake of this question, let's say she found out the tumor regression was the result of binding of Fas Ligand to her carcinoma cells. Show the pathway for this type of death pathway indicating the key factors.

Explanation / Answer

5.a) Necrosis is the premature cell death due to the various external factors, where as apoptosis is the programmed cell death which is initiated by normal health body.

b) Apoptosis triggers are survival factors depletion, hypoxia, loss of cell-matrix interactions etc., where as triggers for necrosis are physicaldamage to the cells, injury of nerve cells, etc.,

c) By performing nucleus changes/ shaping test

d) The E1A oncoprotein induces queiscent cells enter into S phase and it act as potent oncogene, and the mutants lacks the some other proteins so finally it leads to programmedcell death.

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