Which of the following are possible ways to develop into an XY adult who outward

Question

Which of the following are possible ways to develop into an XY adult who outwardly appears female?

Inherit a Y chromosome from your father in which a non-homologous recombination event took place between his X and Y chromosomes that resulted in recombining the SRY gene onto the X chromosome.

Inherit a nonfunctional androgen receptor (located on the X chromosome) allele from both your father and your mother.

Inherit a nonfunctional androgen receptor (located on X chromosome) allele from your mother and a normal Y chromosome from your father.

All three are possible ways.

a and c are both possible.

Inherit a Y chromosome from your father in which a non-homologous recombination event took place between his X and Y chromosomes that resulted in recombining the SRY gene onto the X chromosome.

Inherit a nonfunctional androgen receptor (located on the X chromosome) allele from both your father and your mother.

Inherit a nonfunctional androgen receptor (located on X chromosome) allele from your mother and a normal Y chromosome from your father.

All three are possible ways.

a and c are both possible.

Explanation / Answer

Androgen Insensitivity Syndrome (AIS): The individuals with this syndrome appears as female but they are genetically males (having XY chromosomes)
This genetic disorder follows X-linked recessive pattern, frequently males get affected (due to the single X-chromosome-lack of other compensatory allel)
AR gene on the X-chromosome is mutated in egg before fertilisation or during fetal development.
Answer:
C

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